SrasV1, Main, Exploration, bibRecord, 005A55

Temporal relationship of viral load, ribavirin, interleukin (IL)-6, IL-8, and clinical progression in patients with severe acute respiratory syndrome

Identifieur interne : 005A55 ( Main/Exploration ); précédent : 005A54; suivant : 005A56

Temporal relationship of viral load, ribavirin, interleukin (IL)-6, IL-8, and clinical progression in patients with severe acute respiratory syndrome

Auteurs : Wei-Kung Wang [Taïwan] ; Shey-Ying Chen [Taïwan] ; I.-Jung Liu [Taïwan] ; Chuan-Liang Kao [Taïwan] ; Hui-Ling Chen [Taïwan] ; Bor-Liang Chiang [Taïwan] ; Jann-Tay Wang [Taïwan] ; Wang-Hwei Sheng [Taïwan] ; Po-Ren Hsueh [Taïwan] ; Chao-Fu Yang [Taïwan] ; Pan-Chyr Yang [Taïwan] ; Shan-Chwen Chang [Taïwan]

Source :

Clinical infectious diseases [ 1058-4838 ] ; 2004.

RBID : Pascal:05-0094726

Descripteurs français

Pascal (Inist)
- Syndrome respiratoire aigu sévère, Lymphopénie, Ribavirine, Charge virale, Interleukine 6, Interleukine 8, Coronavirus, Pronostic, Evolution, Homme, Réplication, Réponse immune, Cytokine, Lymphocyte, L-Lactate dehydrogenase, Information thérapeutique, Antiviral.
Wicri :
- topic : Homme.

English descriptors

KwdEn :
- Antiviral, Coronavirus, Cytokine, Evolution, Human, Immune response, Interleukin 6, Interleukin 8, L-Lactate dehydrogenase, Lymphocyte, Lymphocytopenia, Prognosis, Replication, Ribavirin, Severe acute respiratory syndrome, Therapeutic information, Viral load.

Abstract

Although viral replication and overwhelming immune responses are believed to contribute to the progression of severe acute respiratory syndrome (SARS), little is known about the temporal relationship between viral load, ribavirin, proinflammatory cytokines, and clinical progression. We report that ribavirin was not effective in reducing the SARS coronavirus load in 3 of 8 probable cases studied and that elevated levels of interleukin (IL)-6 and IL-8 subsequent to the peak viral load were found in 8 and 6 cases, respectively. The nadir lymphocyte count during lymphopenia, the peak level of lactate dehydrogenase, and the peak density of pulmonary infiltrates lag further behind the peak viral load by a median of 4, 5, and 3.5 days, respectively. These findings provide important information for therapeutic strategies to treat SARS.

Affiliations:

Taïwan

Links toward previous steps (curation, corpus...)

to stream PascalFrancis, to step Corpus: 000734
to stream PascalFrancis, to step Curation: 000256
to stream PascalFrancis, to step Checkpoint: 000755
to stream Main, to step Merge: 005F06
to stream Main, to step Curation: 005A55

Le document en format XML

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<term>Evolution</term>
<term>Human</term>
<term>Immune response</term>
<term>Interleukin 6</term>
<term>Interleukin 8</term>
<term>L-Lactate dehydrogenase</term>
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<front><div type="abstract" xml:lang="en">Although viral replication and overwhelming immune responses are believed to contribute to the progression of severe acute respiratory syndrome (SARS), little is known about the temporal relationship between viral load, ribavirin, proinflammatory cytokines, and clinical progression. We report that ribavirin was not effective in reducing the SARS coronavirus load in 3 of 8 probable cases studied and that elevated levels of interleukin (IL)-6 and IL-8 subsequent to the peak viral load were found in 8 and 6 cases, respectively. The nadir lymphocyte count during lymphopenia, the peak level of lactate dehydrogenase, and the peak density of pulmonary infiltrates lag further behind the peak viral load by a median of 4, 5, and 3.5 days, respectively. These findings provide important information for therapeutic strategies to treat SARS.</div>
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<name sortKey="Sheng, Wang Hwei" sort="Sheng, Wang Hwei" uniqKey="Sheng W" first="Wang-Hwei" last="Sheng">Wang-Hwei Sheng</name>
<name sortKey="Wang, Jann Tay" sort="Wang, Jann Tay" uniqKey="Wang J" first="Jann-Tay" last="Wang">Jann-Tay Wang</name>
<name sortKey="Wang, Wei Kung" sort="Wang, Wei Kung" uniqKey="Wang W" first="Wei-Kung" last="Wang">Wei-Kung Wang</name>
<name sortKey="Yang, Chao Fu" sort="Yang, Chao Fu" uniqKey="Yang C" first="Chao-Fu" last="Yang">Chao-Fu Yang</name>
<name sortKey="Yang, Pan Chyr" sort="Yang, Pan Chyr" uniqKey="Yang P" first="Pan-Chyr" last="Yang">Pan-Chyr Yang</name>
</country>
</tree>
</affiliations>
</record>

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   |wiki=    Sante
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   |clé=     Pascal:05-0094726
   |texte=   Temporal relationship of viral load, ribavirin, interleukin (IL)-6, IL-8, and clinical progression in patients with severe acute respiratory syndrome
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Temporal relationship of viral load, ribavirin, interleukin (IL)-6, IL-8, and clinical progression in patients with severe acute respiratory syndrome

Temporal relationship of viral load, ribavirin, interleukin (IL)-6, IL-8, and clinical progression in patients with severe acute respiratory syndrome

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